TRANSFORM

The biggest trial in prostate cancer screening for 20 years, launched by PC UK.

Overview

The TRANSFORM research project, a £42 million trial launched by PC UK, will be the biggest trial in prostate cancer screening for 20 years. The trial aims to find the best way to screen men for prostate cancer, so that one day, all men at risk are invited for regular tests to find aggressive cancers in time for a cure.

TRANSFORM has been developed in consultation, sponsored by and with the backing of, the NHS, the National Institute for Health and Care Research (NIHR) and the UK Government, who have committed to contribute £16 million. The study is also being supported by founding partners – Movember and the Freddie Green and Family Charitable Foundation, in addition to other significant donations from philanthropic organisations.

There will be multiple points during the trial where new evidence will be generated that might lead to a screening programme. The first point at which we will see significant new evidence will be around three years after it begins.

Phase One

The first phase is due to start in the early part of 2025 and will be over 3 years. In this first phase, involving around 12,500 men, researchers will compare four potential screening options, including fast MRI scans, genetic testing to identify men at high risk of prostate cancer, and PSA blood testing. A fast MRI is a 12-minute version of the full scan that uses magnetic resolution imaging (MRI) to produce a detailed picture of the prostate.

These approaches will also be compared to a control group, where men will follow the current NHS process, they will not be offered a PSA test, but can request one. A control group is vital to prove that any screening programme is more effective than the current process.

Key Features of TRANSFORM

  • There will be a "Control Arm" whereby half the men will not get anything however they will be able to request one.
  • Men who have had a PSA test in the last 5 years will not be eligible.
  • Hospitals who want to be involved have to offer HIFU as a treatment option.
  • "Contamination" is a major concern. If it is above 10-15%, it could derail the whole trial resulting in not only the loss of tens of millions of pounds but also valuable time, as it is it will run for 20 years!
  • The major risk of "Contamination" is somebody being in the "main" arm who the GP was unaware had had a test in the previous 5 years.

The recruitment process will start in the Autumn with the aim of launching in the first quarter of 2025. Please contact us for more information.

Timing Factors in Favour of the Widening Use of HIFU as a Prostate Cancer Treatment

A summary, compiled jointly with Professor Hashim Ahmed of Imperial College.

Please have a read of our overview, and click here to download a PDF summary for more information.

What is HIFU treatment?

HIFU (High-Intensity Focused Ultrasound) is a non-invasive prostate cancer treatment that uses targeted ultrasound waves to destroy cancer cells. This Focal Therapy minimises damage to surrounding tissues, reducing the risk of any potential side effects.

Why is it gaining traction?

HIFU is gaining traction as more younger men, concerned about impotence and incontinence risks, seek safer alternatives. A Consultant Radiologist noted, "The demand for Focal Therapy treatments will explode in the next 10 years" due to these growing concerns.

Support and Fundraising

If you believe you could assist in fundraising to expand these facilities to the Midlands and the North, matching the advanced services available in the South, please contact Graham Fulford at grahamfulford47@gmail.com or call 07831 156071.

We also have access to some powerful films on the subject which you can find under Prostate Cancer Awareness, below.

Prostate Cancer Awareness

Please have a watch of these powerful videos by Prost8 UK, raising awareness for the importance of prostate screening.

Paul's Story - Prostate Cancer and Better Treatments

HIFU for Prostate Cancer - Animation Video

Prost8 - 1 in 8 Fundraiser

Prof. Hashim Ahmed speaks about Focal Therapy options in the treatment of prostate cancer

Prost8 Founder on The Monica Price Show

Paul's Story - Prostate Cancer and Better Treatments (full version)