Published in Urology

Journal Scan / Research · February 27, 2021

European Urology 

TAKE-HOME MESSAGE

• This study prospectively followed more than 40,000 men in the Health Professionals Follow-up Study (1986–2014) to evaluate the impact of diet on prostate cancer. In multivariable-adjusted models, the authors found that there was a 7% higher risk of advanced prostate cancer and a 9% higher risk of fatal prostate cancer in the hyperinsulinemic diet. When stratified by age, the hyperinsulinemic diet was associated with only earlier-onset aggressive prostate cancer. The inflammatory diet was not associated with prostate cancer risk in the overall study population but was associated with earlier-onset lethal prostate cancer.
• Based on this study, hyperinsulinemia and inflammation may be potential mechanisms linking dietary patterns with the risk of aggressive prostate cancer, particularly earlier-onset disease.

– Gautam Jayram, MD